Synthesis and structural characterization of 6-(N-Methyl-pyridin-2-ylcarbamoyl)-pyridine-2-carboxylic acid methyl ester isomers

Maisara Abdul Kadir, and Nafisah Mansor, and Uwaisulqarni Md. Osman, (2017) Synthesis and structural characterization of 6-(N-Methyl-pyridin-2-ylcarbamoyl)-pyridine-2-carboxylic acid methyl ester isomers. Sains Malaysiana, 46 (5). pp. 725-731. ISSN 0126-6039

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Official URL: http://www.ukm.my/jsm/english_journals/vol46num5_2...

Abstract

A series of monoamide isomers have been successfully synthesised and characterised using combination of common spectroscopic techniques such Fourier Transform Infrared (FT-IR), 1H and 13C Nuclear Magnetic Resonance (NMR) and Ultraviolet-visible (UV-vis). The monoamide compounds namely 6-(3-methyl-pyridin-2-ylcarbamoyl)-pyridine-2-carboxylic acid methyl ester (L1), 6-(4-methyl-pyridin-2-ylcarbamoyl)-pyridine-2-carboxylic acid methyl ester (L2), 6-(5-methyl-pyridin-2-ylcarbamoyl)-pyridine-2-carboxylic acid methyl ester (L3) and 6-(6-methyl-pyridin-2-ylcarbamoyl)-pyridine-2-carboxylic acid methyl ester (L4) were prepared from reaction between 6-(methoxycarbonyl)pyridine-2-carboxylic acid with 2-amino-N-methylpyridine (where N = 3, 4, 5 and 6) by using acyl chloride reaction. In this present studies, the synthesis and characterization of these compounds are discussed along with the inductive effects contributed by methyl substituted groups at the pyridine ring.

Item Type:Article
Keywords:Acyl chloride; Inductive; Isomers; Monoamide; Pyridine
Journal:Sains Malaysiana
ID Code:11061
Deposited By: ms aida -
Deposited On:07 Dec 2017 03:59
Last Modified:12 Dec 2017 05:16

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