Cytotoxicity and oxidative stress evaluation of Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast

Nurnadiah Ahmad, and B. Hemabarathy Bharatham, and Zariyantey Abdul Hamid, and Nor Zulaikha Zulkipli, (2017) Cytotoxicity and oxidative stress evaluation of Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast. Jurnal Sains Kesihatan Malaysia, 15 (1). pp. 97-103. ISSN 1675-8161

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Official URL: http://ejournal.ukm.my/jskm/issue/view/635

Abstract

Biocompatibility and growth of osteoblast on bone scaffolds play an important role towards their therapeutic application. The presence of oxidative stress generated by bone scaffolds highly influences osteoblast growth and its functional performance. In this study in-vitro interaction of developed Alginate/Cockle Shell powder nanobiocomposite bone scaffold on osteoblast with regards to cytotoxicity and oxidative stress are evaluated. Cytotoxicity studies using MTT assays revealed a significant increase in viability of cultured osteoblast in the presences of the scaffold extracts. The growth of osteoblast on the scaffold were not deterred with the presence of any major oxidative stress factors as determined through oxidative stress profile studies using SOD, GSH and ROS assays. The nanobiocomposite scaffold evaluated in this study shows promising use in regards to facilitating osteoblast proliferation, growth and viability.

Item Type:Article
Keywords:Nanobiocomposite bone scaffold; Oxidative stress; Osteoblast; Cytotoxicity; Cockle shell powder
Journal:Jurnal Sains Kesihatan Malaysia
ID Code:11463
Deposited By: ms aida -
Deposited On:12 Mar 2018 04:17
Last Modified:16 Mar 2018 01:03

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