Evaluating cardiovascular risk in chronic kidney disease patients: a biomarker approach

Abdul Halim Abdul Gafor, and Rozita Mohd, and Rizna Cader, and Kong, Wei Yen and Marlyn Mohamad, and Shamsul Azhar Shah, and Arbaiyah Bain, and Norella CT Kong, (2018) Evaluating cardiovascular risk in chronic kidney disease patients: a biomarker approach. Sains Malaysiana, 47 (1). pp. 149-155. ISSN 0126-6039


Official URL: http://www.ukm.my/jsm/english_journals/vol47num1_2...


Cardiovascular disease (CVD) is a major cause of morbidity and mortality in chronic kidney disease (CKD) patients. This study aimed to determine the roles of CVD biomarkers in CKD patients. This was a case-control study which recruited consecutive patients with stage 2-4 CKD patients with and without CVD. Serum levels of highly-sensitive C reactive protein (hs-CRP), cystatin C (CysC), asymmetrical dimetylarginine (ADMA) and symmetrical dimethylarginine (SDMA) were measured. Sixty two stage 2-4 CKD patients with a mean age of 60.3 ± 10.4 years were recruited. Twenty three (37.1%) of them had CVD. Those CKD patients with CVD were older (64.1±8.0 vs 58.1± 1.1, p<0.05) and had significantly higher systolic blood pressure (139.4 ± 16.2 vs 129.4 ± 14.8 mmHg, p<0.05). Diabetic patients had 8 times (95% CI 1.25-51.77, p< 0.05) higher risk to develop CVD. CKD patients with CVD had a higher serum creatinine (185.0 ± 54.1 vs 154.1 ± 54.4 μmol/L, p<0.05), a lower estimated glomerular filtration rate (33.7 ± 12.2 vs 42.2 ± 14.5 mL/min/1.73m2 p<0.05) and a lower triglyceride levels (1.3 (1.1-1.7) vs 1.8 (1.4-2.3) mmol/L, p<0.05), compared to those without CVD. Fasting blood sugar was 7.1 ± 2.7 mmol/L in CVD group and 6.3 ± 1.6 mmol/L in non CVD group (p>0.05). There were no differences in their mean serum levels of hs-CRP, CysC, ADMA and SDMA. Risk factors including age, diabetes mellitus, hypertension and renal functions were still the most important CVD risk factors in CKD patients.

Item Type:Article
Keywords:Asymmetrical dimetylarginine; Biomarker; Cardiovascular disease; Chronic kidney disease; Cystatin C
Journal:Sains Malaysiana
ID Code:11991
Deposited By: ms aida -
Deposited On:14 Aug 2018 02:19
Last Modified:17 Aug 2018 09:07

Repository Staff Only: item control page