Effects of durian fruit on blood pressure of spontaneously hypertensive rats

Malina Jasamai, and Nurul Hanis Samsudin, and Norazrina Azmi, and Kumolosasi, Endang (2018) Effects of durian fruit on blood pressure of spontaneously hypertensive rats. Sains Malaysiana, 47 (6). pp. 1221-1226. ISSN 0126-6039


Official URL: http://www.ukm.my/jsm/malay_journals/jilid47bil6_2...


Durian or scientifically known as Durio zibethinus is one of the most well-known seasonal fruits in the Southeast Asia region. However, its safe consumption in individuals with hypertension is still controversial. This study was conducted to investigate the effect of durian on blood pressure of spontaneously hypertensive rat model. Four groups of rats (n=5) were fed with either a low dose durian (26 g/kg), a high dose durian (52 g/kg), sugar solution (8 mL/kg) which has similar sugar composition in the durian as placebo control, and distilled water as vehicle control (8 mL/kg) for 14 days. The durian doses for rats were obtained by converting from human doses. Baseline reading of blood pressure and heart rate were recorded before the first oral administration of durian. The blood pressure and heart rate were also measured 1 h after the durian oral administration on day 1, 3, 7 and 14 of the experiment. In conclusion, durian fruit possessed an acute effect on the blood pressure of hypertensive rats but heart rate was unaffected. High dose administration of durian led to significant elevation of blood pressure after 1 h of consumption. Meanwhile, low dose of durian (26 g/kg) caused an insignificant reduction in systolic and diastolic blood pressure. Tolerance to the durian fruit was observed after three to seven days of the oral administration and low dose consumption of durian fruit was safe in the hypertensive rat.

Item Type:Article
Keywords:Blood pressure; Durian; Heart rate; Hypertension; spontaneously hypertensive rats
Journal:Sains Malaysiana
ID Code:12126
Deposited By: ms aida -
Deposited On:24 Sep 2018 07:14
Last Modified:28 Sep 2018 22:40

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