Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design

Asmawati M. Sail, and Wan Aida Wan Mustapha, and Salma Mohamad Yusop, and Mohamad Yusof Maskat, and Ahmad Fuad Shamsuddin, (2018) Optimisation of cinnamaldehyde-in-water nanoemulsion formulation using central composite rotatable design. Sains Malaysiana, 47 (9). pp. 1999-2008. ISSN 0126-6039


Official URL: http://www.ukm.my/jsm/english_journals/vol47num9_2...


Thirteen formulations of cinnamaldehyde/non-ionic surfactant/water system nanoemulsions were prepared using high-pressure homogenisation. The result showed that varying the cinnamaldehyde/surfactant ratio had effect significantly (p<0.05) to mean droplet diameter, polidispersity index, ζ-potential, turbidity and whiteness index, while no significant effect (p>0.05) to viscosity. The mean droplet diameter ranged from 50.48 to 106.4 nm, polydispersity index from 0.06 to 0.28 and ζ-potential from -4.11 to -6.98 mV. The smallest droplet size was produced using 5% cinnamaldehyde and 5% Tween 80. Response surface for droplet diameter showed that the higher the cinnamaldehyde and surfactant concentrations, the larger the droplet diameter, polydispersity index and whiteness index. However, the ζ-potential increased as the cinnamaldehyde concentration decreased and Tween 80 increased. Increasing the cinnamaldehyde concentration led to an increase in turbidity. Formulation of 5% cinnamaldehyde and 6.23% Tween 80 gave no observable separation of the nanoemulsion with minimum droplet size, polidispersity index, viscosity, turbidity, whiteness index and maximum ζ-potential in modulus. The stability of the optimum formulation was sustained for 10 days upon storage at 4°C. The values of droplet diameter, PDI and ζ-potential were 55.50 nm, 0.08 and -5.38 mV, respectively.

Item Type:Article
Keywords:Cinnamaldehyde; Formation; High-pressure homogenisation; Nanoemulsion; Optimisation
Journal:Sains Malaysiana
ID Code:12388
Deposited By: ms aida -
Deposited On:04 Dec 2018 08:11
Last Modified:07 Dec 2018 23:21

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