Antibacterial activity and major constituents of Polyalthia cinnamomea basic fraction

Puteri I.A.M.Mahmud, and Wan A. Yaacob, and Nazlina Ibrahim, and Muntaz Abu Bakar, (2018) Antibacterial activity and major constituents of Polyalthia cinnamomea basic fraction. Sains Malaysiana, 47 (9). pp. 2063-2071. ISSN 0126-6039


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Polyalthia cinnamomea Hook.f. & Thomson (Annonaceae) or locally known as ‘Larak Batu Bukit’, ‘Pisang-pisang’, ‘Sugao’ and ‘Sigumpet Hutan’ is a small woody plant found throughout Malaysia and Singapore. In this study, the basic chemical components from the leaves of the plant were fractionated and the antibacterial activity as well as the major constituents of the basic fraction was determined. To the best of our knowledge, this is the first study being carried out on the bioactivity and phytochemistry of P. cinnamomea. The basic fraction remarkably inhibited the growth of ten bacteria tested except one. The biggest inhibitory diameter and the lowest minimum inhibitory concentration were 19.0±4.6 mm and 0.125 mg/mL against respective Bacillus subtilis and Bacillus thuringiensis. Gas chromatography-mass spectrometry (GCMS) analysis of the basic fraction identified four major cyclosiloxanes of octamethylcyclotetrasiloxane (18.1%), decamethylcyclopentasiloxane (16.4%), dodecamethylcyclohexasiloxane (14.1%) and tetradecamethylcycloheptasiloxane (6.0%). The knowledge of the antibacterial potential of P. cinnamomea basic fraction and the major constituents present in the fraction can be utilized in the fields of natural products, pharmaceutical, cosmetic and personel care industries.

Item Type:Article
Keywords:Antibacterial activity; Basic fraction; Cyclosiloxane; Polyalthia cinnamomea
Journal:Sains Malaysiana
ID Code:12395
Deposited By: ms aida -
Deposited On:05 Dec 2018 03:08
Last Modified:07 Dec 2018 23:28

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