Multi-disciplinary approach for managing plasmacytoma: a case report

Wint Wint Thu Nyunt, and Rahayu Draman, and Aida Widure Mohd Mustapha, and Noralisa Abdul Karim, and Mohd Razif Mohd Idris, and Noraimy Abdullah, and Tang, Yee Loong and Wan Fariza Wan Jamaludin, and Noraidah Masir, and S Fadilah S Abdul Wahid, (2018) Multi-disciplinary approach for managing plasmacytoma: a case report. Sains Malaysiana, 47 (9). pp. 2113-2118. ISSN 0126-6039


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Solitary plasmacytoma (SP) is a tumor with evidence of clonal plasma cells and no other features of multiple myeloma (MM). We report a case of SP which showed multiple recurrences of SP and then evolution into overt MM. A 56-year-old man presented with the 5-month-history of right nasal obstruction and intermittent epistaxis. He had SP (extraosseous) of right nasopharynx (3.5 × 2 × 2.5 cm), with no paraproteinaemia. He received radiotherapy (56 Gy), achieving complete remission. Ten years later, he had recurrence of SP (osseous) in left tibia, presenting with pathological fracture. He received radiotherapy (50 Gy), achieving partial response. Three years later, he had recurrence of SP (osseous) in right tibia, presenting with right leg pain. He received radiotherapy (45 Gy). While receiving treatment, he had progressive swelling in the area around right eye, double vision and headache. Imaging scans showed multiple plasmacytomas. There were presence of monoclonal paraprotein, hypercalcemia and lytic bone lesions. He was diagnosed as MM (at the age of 70 years) and treated with Bortezomib-based therapy. Currently, after one cycle of treatment, clinical improvement is achieved. The importance of multi-disciplinary team approach for managing patients with plasmacytoma is highlighted in order to achieve the holistic approach of management.

Item Type:Article
Keywords:Multiple myeloma; Plasmacytoma; Plasma cell proliferative disorder
Journal:Sains Malaysiana
ID Code:12402
Deposited By: ms aida -
Deposited On:05 Dec 2018 08:03
Last Modified:07 Dec 2018 23:36

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