Challenges in parathyroid cancers: a review

Sujith Indeewara Wijerathne, and Rajeev Parameswaran, (2018) Challenges in parathyroid cancers: a review. Journal of Surgical Academia, 8 (1). pp. 5-15. ISSN 2231-7481


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Parathyroid carcinomas are rare neoplasms, with a reported incidence of less than 1% of cases of primary hyperparathyroidism. Diagnosis and treatment of parathyroid carcinoma remains a challenge, as many of the pathologic features are neither sensitive nor specific in differentiating from benign parathyroid lesions. The rule of 3’s (serum calcium of more than 3mmol/L and size of the adenoma being more than 3cm) is helpful in risk identifying a cancer. Ultrasound of the neck and Tc-99m pertechnetate/Tc-99m sestamibi (MIBI) scan remains the two main modalities of investigation of parathyroid disease. Although en-bloc treatment is recommended for parathyroid cancer, it is only performed in up to 12% of cases. This review illustrates the challenges in diagnosis and treatment of parathyroid carcinoma.

Item Type:Article
Keywords:Cancer; Genetic; Hypercalcaemia; Hyperparathyroidism; Parathyroid
Journal:Journal of Surgical Academia
ID Code:12550
Deposited By: ms aida -
Deposited On:11 Feb 2019 23:50
Last Modified:14 Feb 2019 13:51

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