3D titanium scaffold properties and osteogenesis of stem cells

Rohaya Megat Abdul Wahab, and Manal Nabil Hagar, and Nur Atmaliya Luchman, and Farinawati Yazid, and Shahrul Hisham Zainal Ariffin, (2020) 3D titanium scaffold properties and osteogenesis of stem cells. Sains Malaysiana, 49 (4). pp. 809-816. ISSN 0126-6039


Official URL: http://www.ukm.my/jsm/malay_journals/jilid49bil4_2...


Studies on porous titanium for use in dental applications have been growing due to their excellent properties such as low elastic modulus, biocompatibility and excellent strength. The porosity and pore size of titanium scaffold play an important role in bone formation. Thus, this paper reviews the properties of titanium scaffold and the relationship between the porosity and pore size of titanium with the osteogenesis of stem cells in respect of its mechanical properties and biological assessment. From this review, it was found that a pore size of less than 300 μm allows for good vascularization that can lead to direct osteogenesis without an interphase of cartilage formation. The minimum requirement for pore size is approximately 100 μm to assist in the migration requirement, cell size and transport, as a smaller pore size causes a hypoxic condition and induces osteochondral formation before osteogenesis, while a pore size from 500 to 1000 μm affects the differentiation of the stem cells. In addition, it was found that high porosity induces osteogenesis. The average porosity of the scaffold for cell proliferation was between 25-50 μm. In conclusion, highly porous titanium is a useful modern material for creating 3D structures for bone regeneration and implant fixation.

Item Type:Article
Keywords:Bone regeneration; Pore size; Porosity; Stem cell; Titanium scaffold
Journal:Sains Malaysiana
ID Code:15352
Deposited By: ms aida -
Deposited On:12 Oct 2020 08:15
Last Modified:16 Oct 2020 00:47

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