Mesenchymal stem cell therapy for sports injuries - from research to clinical practice

Looi, Qi Hao and Eng, Sue Ping and Liau, Ling Ling and Tor, Yin Sim and Mohd Yazid Bajuri, and Ng, Min Hwei and Law, Jia Xian (2020) Mesenchymal stem cell therapy for sports injuries - from research to clinical practice. Sains Malaysiana, 49 (4). pp. 825-838. ISSN 0126-6039


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The number of sports-related injuries is on the rise as more people are involved in sports, especially the extreme sports that are prone to injury. A serious sports injury might end the career of an athlete. Thus, prompt and effective treatment is very important for these injuries. Cell-based therapy is becoming more popular as a potential new treatment for sports injuries that are refractory to conventional therapy. Mesenchymal stem cells (MSCs) are commonly used in the treatment of sports injuries as they are safe and will not be rejected by the recipient. MSCs secrete paracrine factors that modulate the host immune response, promote angiogenesis, enhance cell migration and survival as well as prevent fibrosis. The safety and efficacy of MSC therapy in treating sports injuries involving the muscle, ligament, tendon, bone, cartilage, and nervous tissues have been demonstrated in many preclinical and clinical studies. However, more studies especially the large-scale randomized clinical trial need to be done in order to determine the adequacy of MSC therapy in treating different sports injuries. In this review, we discussed the treatment for sports injuries, focusing on MSC therapy, using data from preclinical and clinical studies.

Item Type:Article
Keywords:Mesenchymal stem cell; Orthopedics; Regenerative medicine; Sports injury; Stem cell therapy
Journal:Sains Malaysiana
ID Code:15354
Deposited By: ms aida -
Deposited On:13 Oct 2020 00:26
Last Modified:16 Oct 2020 00:50

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