Achmad Zainuddin, and Sylvia Rachmawati Meilanie, and Darwati, and Kurniawan, and Nurlelasari, and Tati Herlina, and Saputra, Adrian Rizky and Al Anshori, Jamaludin and Tri Mayanti, (2020) Cytotoxic triterpenoids from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum against MCF-7 breast cancer cell. Sains Malaysiana, 49 (5). pp. 989-994. ISSN 0126-6039
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Official URL: http://www.ukm.my/jsm/english_journals/vol49num5_2...
Abstract
Three triterpenoids, taraxerone (1) and 18-epi-taraxerol (2), and masticadienolic acid (3) were isolated for the first time from the stem barks of Dysoxylum arborescens and Dysoxylum excelsum, respectively. Isolation of the compounds was achieved by various extraction and chromatography column techniques, while their chemical structures were elucidated based on spectroscopic data and literature comparison. Compounds 1, 2, and 3 were found to show inhibitory activity against MCF-7 breast cancer cells with IC50 values 792.9, 59.6, and 3.5 µM correspondingly.
| Item Type: | Article |
|---|---|
| Keywords: | Dysoxylum arborescens; Dysoxylum excelsum; MCF-7; Triterpenoids |
| Journal: | Sains Malaysiana |
| ID Code: | 15389 |
| Deposited By: | ms aida - |
| Deposited On: | 19 Oct 2020 02:51 |
| Last Modified: | 23 Oct 2020 00:45 |
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