Secondhand smoke exposure and autism spectrum disorder: a meta-analysis

Fadzrul Hafiz Johani, and Nur Ezdiani Mohamed, and Mohd Shafik Abd Majid, and Siti Diyana Ibrahim, and Zaleha Md Isa, (2020) Secondhand smoke exposure and autism spectrum disorder: a meta-analysis. Sains Malaysiana, 49 (7). pp. 1615-1625. ISSN 0126-6039


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Nicotine exposure during early life can significantly affect neurocognitive development. This meta-analysis was conducted to explore whether an association exists between secondhand smoke (SHS) exposure and risk of autism spectrum disorder (ASD) in children. Database search using PubMed, SAGE, Scopus, ScienceDirect, ProQuest, and Google Scholar were used to search observational studies from January 2009 until January 2020. The random-effect model was used to combine results from individual studies. Four studies (2 cross-sectional studies, 1 case-control study, and 1 mixed design study) with 2,434 ASD cases and a total of 104,128 participants were included in the analysis. The pooled odds ratio (OR) was 1.36 (95% confidence interval (CI): 1.25-1.49) comparing SHS exposure in children with those who were not exposed. Heterogeneity was not significant across studies (Chi2 = 0.41, p = 0.94, I2 = 0%). Results from this meta-analysis indicated that SHS exposure has significant association with risk of ASD in children. Current findings should be confirmed through more studies including prospective cohort studies.

Item Type:Article
Keywords:Autism spectrum disorder; Children; Meta-analysis; Secondhand smoke
Journal:Sains Malaysiana
ID Code:15624
Deposited By: ms aida -
Deposited On:09 Nov 2020 03:40
Last Modified:11 Nov 2020 16:34

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