Assessment of anticoccidial efficacy of novel Triazine compound and Sulfaclozine against experimentally induced caecal coccidiosis in broiler chickens

Hagag, Dina and El-Shazly, Kamal and Abd El-Aziz, Magdy and Abd El-Latif, Amira and El Sharkaway, Hanem and Abdo, Walied and Barakat, Mohamed (2020) Assessment of anticoccidial efficacy of novel Triazine compound and Sulfaclozine against experimentally induced caecal coccidiosis in broiler chickens. Sains Malaysiana, 49 (11). pp. 2637-2648. ISSN 0126-6039

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Official URL: https://www.ukm.my/jsm/malay_journals/jilid49bil11...

Abstract

This study was performed to investigate the theraputic efficacy of toltrazuril, sulfaclozine sodium and their combination in broiler chicken for the treatment of experimentally induced caecal coccidiosis. For this purpose, seventy-five day-old chicks were randomly divided into five equal groups (15 each). G1 , kept as control negative; G2 , infected non treated (control positive); G3 , infected treated with toltrazuril (1 mL/L); G4 , infected treated with sodium sulfaclozine (2 mL/L); G5 , infected treated with toltrazuril (1 mL/L) + sulfaclozine Na (2 g/L). All groups except negative control group were inoculated orally with 5 × 104 sporulated oocysts of Eimeria tenella (field isolate) on the day 15th of age. According to the present results, G2 showed a significant increase in oocyst count, AST, ALT, ALP, uric acid, and creatinine, with significant decrease in body weight gain, hematological parameters, total protein, and albumin. Treatment decreased the harmful effect of infection but some significant differences were shown between infected and treated groups and non infected and non treated group in assessment criteria. Furthermore, the histopathological findings were also discussed. In conclusion, the current study showed that the application of both tested drugs gave significant and satisfactory improvement in the assessment criteria as well as they are effective in control of coccidiosis caused by Eimeria tenella.

Item Type:Article
Keywords:Broiler; E. tenella experimental infection; Egypt; Sulfaclozine sodium; Toltrazuril
Journal:Sains Malaysiana
ID Code:15994
Deposited By: ms aida -
Deposited On:16 Dec 2020 07:45
Last Modified:17 Dec 2020 04:41

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