Chemical constituents and biological activities of Mitrella kentii (Blume) miq. leaf oil

Juriyati Jalil, and Sakina Saadawi, and Ibrahim Jantan, and Malina Jasamai, (2021) Chemical constituents and biological activities of Mitrella kentii (Blume) miq. leaf oil. Jurnal Sains Kesihatan Malaysia, 19 (1). pp. 151-159. ISSN 1675-8161


Official URL:


Chemical constituents and biological activities of the Mitrella kentii leaf oil were investigated in this study. Gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) were used to determine the chemical constituents of the oil. The oil was evaluated for its ability to inhibit prostaglandin E2 (PGE2 ) and thromboxane B2 (TXB2 ) productions in human whole blood using a radioimmunoassay technique. Its inhibitory effect on platelet�activating factor (PAF) receptor binding with rabbit platelets using 3 H-PAF as a ligand and its free radical scavenging effect on DPPH were also investigated. Caryophyllene oxide (33.8%w/w), E,Z-farnesol (6.9%), benzyl benzoate (6.5%w/w) and viridiflorol (6.5%w/w) were among the major components of the oil. Even though weak inhibitory activities were observed in both PGE2 and TXB2 assays, significant results were obtained in both PAF receptor binding inhibition and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging effect with IC50 value of 6.6 µg/mL and 155.6 µg/mL respectively. These promising activities warrant the development of the oil as an anti-inflammatory agent.

Item Type:Article
Keywords:Mitrella kentii; Platelet-activating factor (PAF); Prostaglandin E2 (PGE2); Thromboxane B2 (TXB2); DPPH assay
Journal:Jurnal Sains Kesihatan Malaysia
ID Code:16641
Deposited By: ms aida -
Deposited On:20 May 2021 04:32
Last Modified:25 May 2021 03:12

Repository Staff Only: item control page