Grape seed proanthocyanidin improves lipopolysaccharide-induced myocardial toxicity in mice

Liu, Xianchu and Li, Sha and Chen, Ruyan and Li, Yue and Liu, Ming and Peng, Huan (2021) Grape seed proanthocyanidin improves lipopolysaccharide-induced myocardial toxicity in mice. Sains Malaysiana, 50 (4). pp. 945-952. ISSN 0126-6039


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Lipopolysaccharide (LPS) is an important pathogenic factor for sepsis which results in cardiovascular diseases and even mortality. Proanthocyanidin, one of the main components in grape seed, has a wide range of biological activities in various diseases. The mouse model was established by intraperitoneal injection with LPS. Grape seed proanthocyanidin (GSP) was administered continuously for 8 days. Our results showed that pre-treatment of GSP dramatically ameliorated the level of creatine kinase (CK) and lactate dehydrogenase (LDH) to defend against LPS-induced myocardial toxicity (p<0.01). Moreover, pre-treatment of GSP significantly mitigated the expression of matrix metallopeptidase 2 (MMP-2) and matrix metallopeptidase 9 (MMP-9) to inhibit LPS-induced myocardial fibrosis (p<0.01). In addition, pre-treatment of GSP significantly increased superoxide dismutase (SOD) and catalase (CAT) activities to improve the level of malondialdehyde (MDA) and hydrogen peroxide (H2 O2 ) (p<0.01). Lastly, pre-treatment of GSP relieved tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) activities to prevent inflammatory responses (p<0.01).

Item Type:Article
Keywords:Anti-inflammatory; Anti-oxidant; Grape seed proanthocyanidin; Heart; Lipopolysaccharide
Journal:Sains Malaysiana
ID Code:17168
Deposited By: ms aida -
Deposited On:22 Jul 2021 01:32
Last Modified:26 Jul 2021 02:34

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