Interferences of HbA1c analysis in Hospital Universiti Sains Malaysia – 3 years study

Noorazliyana Shafii, and Noor Azlin Azraini Che Soh, and Tuan Salwani Tuan Ismail, and Julia Omar, and Wan Norlina Wan Azman, and Aniza Mat Jelani, and Wan Nor Fazila Hafizan Wan Nik, and Ibrahim Ismail, and Nur Karyatee Kassim, and Hanim Afzan Ibrahim, and Najib Majdi Yaacob, (2021) Interferences of HbA1c analysis in Hospital Universiti Sains Malaysia – 3 years study. Malaysian Applied Biology, 50 (2). pp. 19-23. ISSN 0126-8643


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Haemoglobin A1c (HbA1c) is used to monitor glycaemic control and predict diabetic complications. Measurement of HbA1c can be interfered by haemoglobin (Hb) variant and other Hb derivatives include carbamylated Hb and elevated labile A1c. This study is to determine the percentages and type of interferences during HbA1c analysis and the percentages of nonreportable HbA1c results. This is a cross-sectional study using retrospective data of HbA1c. The HbA1c is measured on Biorad D10 using the ion-exchange high-performance liquid chromatography method. The data were analyzed using descriptive statistics. A total of 26,560 patients were included. The result showed the presence of interferences of 2269 (8.56%). The most common causes of the interferences were the Hb variant (8.48%) followed by carbamylated Hb and labile A1c (0.03% each). The non-reportable HbA1c results were 0.46% with the Hb variant contributed most of the causes. By knowing the presence of interferences particularly the Hb variant, the HbA1c results hopefully are interpreted with caution and correct management can be given to the patients.

Item Type:Article
Keywords:Carbamylated haemoglobin; Haemoglobin variants; HbA1c; HPLC; Interferences; Labile A1c
Journal:Malaysian Applied Biology Journal
ID Code:18810
Deposited By: ms aida -
Deposited On:21 Jun 2022 00:33
Last Modified:24 Jun 2022 00:33

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