Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model

Anis Syahirah Mohd Shafie, and Che Badariah Abd Aziz, and Liza Noordin, and Idris Long, and Anani Aila Mat Zin, and Rosfaiizah Siran, (2021) Tualang honey modulated nociceptive responses in the thalamus of rem sleep deprivation rat model. Malaysian Applied Biology, 50 (3). pp. 39-47. ISSN 0126-8643


Official URL: https://jms.mabjournal.com/index.php/mab/issue/vie...


Sleep deprivation has been shown to alter pain responses in humans and animals. The present study investigated whether the administration of Tualang honey in the rapid eye movement (REM) sleep deprivation rat model would modulate nociceptive responses with associated changes in the thalamus. Forty-eight Sprague Dawley male rats were randomised into four groups (n=12 for each group): control group (FMC), REM sleep deprivation (REMsd), REM sleep deprivation pretreated with Tualang Honey for 1 month (REMsdH) and tank control (TC). Following sleep deprivation for 72 hours, a formalin test was conducted and pain behaviour was recorded and analysed. The rats were sacrificed, and the brains were removed for histological examination and assessment of N-methyl-D-aspartate receptor (NMDA R2) level in the thalamus. REMsdH group showed a significantly lower level of pain behaviour score and NMDA R2 compared to the REMsd group (p<0.05). In addition, REMsdH also demonstrated a significantly higher number of Nissl stained neurons in comparison with the REMsd group (p<0.05). Furthermore, dark neurons, suggestive of neuronal damage, were observed in the REMsd group. In conclusion, administration of Tualang honey before REM sleep deprivation modulated nociceptive responses and prevent changes in thalamic neurons and NMDA R2 level.

Item Type:Article
Keywords:NMDA receptor; Pain; REM sleep deprivation; Thalamus; Tualang honey
Journal:Malaysian Applied Biology Journal
ID Code:18879
Deposited By: ms aida -
Deposited On:29 Jun 2022 01:28
Last Modified:05 Jul 2022 07:38

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