Hepatitis B virus genotypes and mutations affecting HBeAg production: A Malaysian perspective

Chee, Kent Lim and So, Har Ton (2007) Hepatitis B virus genotypes and mutations affecting HBeAg production: A Malaysian perspective. Medicine & Health, 2 (1). pp. 1-25. ISSN 1823-2140 (In Press)


Official URL: http://www.ppukm.ukm.my/ukmmcjournal/index.php


Infection by hepatitis B virus (HBV) is a major global health-care problem. HBV is an accepted factor in the elevated risks for liver disease such as cirrhosis and development of hepatocellular carcinoma. This problem is particularly prevalent in the Asia-Pacific region which includes Malaysia. During infection, the hepatitis B e antigen (HBeAg) is produced in the hosts. This antigen is an important serological marker for diagnosing chronic hepatitis B. Seroconversion to anti-body (anti-HBe) corresponds to the improvement of disease prognosis. However, certain mutations such as the core promoter dual mutations (A1762G1764→T1762A1764), the codon 15 variants (C1858/ T1858) and the precore stop codon mutations (TGG→TAG) can affect the HBeAg expression. This has diagnostic and clinical implications. Besides that, the HBV can be grouped into eight genotypes (A to H).Moreover, genotypic subtypes and recombinants have been observed as well. Studies have observed that these can differ in their affiliations with the mutations above as well as with disease prognosis

Item Type:Article
Keywords:Hepatitis B virus (HBV); genotypes; core promoter double mutations; codon 15 variants; pre-core stop codon mutation
Journal:Medicine & Health
ID Code:1924
Deposited By: mr Mustaffa Abu Bakar
Deposited On:20 Jun 2011 03:25
Last Modified:14 Dec 2016 06:30

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