Chemical constituents and anti-neuroblastoma activity from Boesenbergia stenophylla

Phoebe Sussana Primus, and Muhammad Hazran Ismail, and Nabila Elyana Adnan, and Wu, Carol Hsin-Yi and Kao, Chai-Lin and Choo, Yeun-Mun (2022) Chemical constituents and anti-neuroblastoma activity from Boesenbergia stenophylla. Sains Malaysiana, 51 (4). pp. 1075-1084. ISSN 0126-6039


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Three diarylheptanoids and one flavonoid, i.e. 7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (4), 5R-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenylheptan-3-one (5), 1,7-diphenylhept-4-en-3-one (6), and 3,5,7-trihydroxyflavone (7) were isolated and characterized from the rhizome of Boesenbergia stenophylla. Compounds 2 and 4 displayed excellent anti-neuroblastoma activity which reduces the cell viability to 30% and 20%, respectively. The results from the molecular docking experiments targeting the protein kinases regulating neuroblastoma cell survival (PI3K/AKT1 signalling pathway) are consistent with that of the in vitro results. Finally, the structures of 4-7 were elucidated using spectroscopic methods (UV, IR, NMR, and HRESIMS).

Item Type:Article
Keywords:AKT1; Anti-neuroblastoma; Boesenbergia stenophylla; N2A; PI3K
Journal:Sains Malaysiana
ID Code:19272
Deposited By: ms aida -
Deposited On:04 Aug 2022 03:40
Last Modified:08 Aug 2022 06:20

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