Effect of protein A-immunoadsorption therapy on serum cytokines in AAV patients

Li, Xiejia and Li, Zheng and Deng, Hongmei and Sun, Cuifang and Liu, Hong and Yuan, Fang (2022) Effect of protein A-immunoadsorption therapy on serum cytokines in AAV patients. Sains Malaysiana, 51 (4). pp. 1155-1165. ISSN 0126-6039


Official URL: https://www.ukm.my/jsm/malay_journals/jilid51bil4_...


Protein A-immunoadsorption (IA) is an extracorporeal apheresis technique used in patients with autoimmune diseases which aims to remove pathogenic autoantibodies. Apart from the adsorption of immunoglobulins (IgG), IA may influence cellular and humoral immunity. The aim of this study was to observe the effect of protein A-IA on cytokine networks in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients. A total of 12 newly diagnosed AAV patients received IA therapy on days 1, 3, and 5. Serum levels of inflammatory cytokines were measured before and after treatment including members of the interleukin family, PDGF-BB, TNF-α and IFN-γ. IL-1β, IL-9, IL-17A, PDGF-BB, IFN-γ, and TNF-α were elevated in AAV patients compared to healthy individuals. There were no changes in the levels of any cytokines after the first IA session but after 3 sessions, IL-9, PDGF-BB, and TNF-α dramatically decreased. Moreover, reductions in IL-9 levels were positively correlated with the changes of myeloperoxidase-ANCA (MPO-ANCA). Our observations suggest that protein A-IA therapy does not directly adsorb cytokines, but removes autoantibodies (MPO-ANCA) which indirectly leads to changes in cytokine networks linked to cellular or humoral immunity.

Item Type:Article
Keywords:Cytokines; Immunoadsorption; Protein-A, ANCA; Vasculitis
Journal:Sains Malaysiana
ID Code:19279
Deposited By: ms aida -
Deposited On:04 Aug 2022 06:10
Last Modified:08 Aug 2022 06:41

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