Kernel smoothing for ROC curve and estimation for thyroid stimulating hormone

Tazhibi Mehdi, and N, Bashardoost and M, Ahmadi (2011) Kernel smoothing for ROC curve and estimation for thyroid stimulating hormone. International Journal of Public Health Research, Specia . pp. 239-242. ISSN 2232-0245

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Official URL: http://www.ijphr.ukm.my/

Abstract

Receiver Operating Characteristic (ROC) Curves are frequently used in biomedical informatics research to evaluate classification and prediction models to support decision, diagnosis, and prognosis. ROC analysis investigates the accuracy of models and has ability to separate positive from negative cases. It is especially useful in evaluating predictive models and compare to other tests which produce output values in a continuous range. Empirical ROC curve is jagged but a true ROC curve is smooth. For this purpose kernel smoothing were used. The Area Under ROC Curve (AUC) frequently is used as a measure of the effectiveness of diagnostic markers. In this study we compare estimation of this area based on normal assumptions and kernel smoothing. This study used measurements of TSH from patients and non-diseased people of congenital hypothyroidism screening in Isfahan province. Using the method, TSH ROC curves from Isfahani's infants were fitted. For evaluating of accuracy of this test, AUC and its standard error calculated. Also effectiveness of the kernel methods in comparison to other methods showed.

Item Type:Article
Keywords:Kernel Smoothing; ROC Curve; Thyroid Stimulating Hormone
Journal:International Journal of Public Health Research
ID Code:3560
Deposited By: Mr Azam
Deposited On:21 Feb 2012 03:23
Last Modified:14 Dec 2016 06:34

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