Danial Yahya, M. and Chien , C. Lung and Yacob L. Pinnas, (1996) Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain. Sains Malaysiana, 25 (1). pp. 77-86. ISSN 0126-6039
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Official URL: http://www.ukm.my/jsm/english_journals/vol25num1_1...
Abstract
The levels of malondialdehyde (MDA)-specific antibodies in lupus-prone MRL/ lpr mice of different ages were compared to those against DNA. These mice elicited anti-MDA antibodies earlier and in higher levels that anti-DNA antibodies. The levels of immune complexes containing MDA adducts were also higher in these mice when compared to 3 other non-lupus strains. MDA binding to a 100 kDa serum protein was observed in 3 and 5 month old mice. Immune complexes involving anti-MDA antibodies and MDA adducts may represent an additional mechanism that contributes to disease pathogenesis in these mice.
| Item Type: | Article |
|---|---|
| Keywords: | antibodi anti-malondialdehida (MDA);anti-DNA antibodies |
| Journal: | Sains Malaysiana |
| ID Code: | 3681 |
| Deposited By: | Mr Fazli Nafiah - |
| Deposited On: | 15 Mar 2012 05:03 |
| Last Modified: | 29 Mar 2012 04:33 |
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