DNA repair at the gene level in trichothiodystrophy cells

Nathan , Sheila and Mayne, Lynne (2000) DNA repair at the gene level in trichothiodystrophy cells. Sains Malaysiana, 29 . pp. 19-31. ISSN 0126-6039

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Official URL: http://www.ukm.my/jsm/english_journals/vol29_2000/...


Cells from trichothiodystrophy (TTD) group 3 patients are non-hypersensitive to uv irradiation. These cells perform normal genome repair of pyrimidine dimers but fail to excise 6-4 photoproducts and concomitantly, are unable to restore RNA synthesis levels following uv irradiation. This pointed to a defect in gene-specific repair and this study was undertaken to examine repair of dimers at the gene-level. The results indicated a defect in gene-specific repair of dimers at early times post-irradiation due to the inability of the cells to repair dimers from the transcribed strand of the active gene. These findings indicate that TTD group 3 cells are unable to remove DNA lesions preferen­tially and this might contribute to other inherent symptoms of these patients.

Item Type:Article
Journal:Sains Malaysiana
ID Code:3779
Deposited By: Mr Fazli Nafiah -
Deposited On:20 Mar 2012 01:56
Last Modified:20 Mar 2012 01:56

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