Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats

Zahidah, A.F and Faizah, O and Nur Aqilah, K and Taty Anna, K (2012) Curcumin as an anti-arthritic agent in collagen-induced arthritic sprague-dawley rats. Sains Malaysiana, 41 (5). pp. 591-595. ISSN 0126-6039


Official URL:


Curcuma longa or turmeric has long been used in traditional medicine by the local population in Malaysia as an antiinflammatory agent. It has been proven to contain natural antiarthritic compound called curcumin. Joints abnormality and destruction have been implicated in the pathogenesis of rheumatoid arthritis (RA) due to inflammatory reactions. In this study, collagen-induced arthritis (CIA) model was utilized to study the effects of curcumin on joint inflammation in Sprague-Dawley rats. Body weight measurement, arthritis score assessment and radiology score assessment were carried out at specific intervals throughout this study. The results showed that the mean arthritis and radiology scores for animal groups designated as CIA CurcuminC and CIA CurcuminT were significantly lower compared with the negative control (CIA OV) group respectively. The mean arthritis scores for CIA CurcuminC group is significantly lower compared with CIA CurcuminT group but there is no significant difference in the mean radiology scores between the CIA CurcuminC and CIA CurcuminT groups. In conclusion, the oral supplementation of curcumin at the dose of 110 mg/mL/kg/day has a potential to delay and improve joint abnormality and injury in Sprague-Dawley rats with CIA.

Item Type:Article
Keywords:Arthritis score; collagen-induced arthritis; curcumin; radiology score
Journal:Sains Malaysiana
ID Code:4472
Deposited By: Mr Azam
Deposited On:23 Apr 2012 09:20
Last Modified:14 Dec 2016 06:36

Repository Staff Only: item control page