Hui-min, Neoh and Mee, Lee Looi and Muhiddin Ishak, and Mohd Ridhwan Abd Razak, and Noor Hamidah Hussin, and Zarina Latiff, and Hamidah Alias, and Rahman Jamal, (2012) Positive TPMT genotype-phenotype correlation underscores importance of TPMT genotyping for personalized thiopurine dosing. Asia-Pacific Journal of Molecular Medicine, 2 ((1):1). pp. 1-3. ISSN 2232-0326
![[img]](http://journalarticle.ukm.my/style/images/fileicons/application_pdf.png) |
PDF
Restricted to Repository staff only 88kB |
Official URL: http://www.ukm.my/apjmm/
Abstract
This study explored TPMT genotype-phenotype correlation in a group of acute lymphoblastic leukemia (ALL) patients to investigate the potential of TPMT genotyping for personalized thiopurine dosing. Genotyping for G238C (TPMT*2), G460A (TPMT*3B) and A719G (TPMT*3C) loci was determined in 89 subjects via PCR, while TPMT activity was measured using HPLC. TPMT*3C was the only mutant allele detected in 4 heterozygous carriers. These patients had significantly lower (23.0 nmol/g Hb/h) TPMT activity compared to wildtype patients (51.0 nmol/g Hb/h) (p = 0.003). Positive correlation between TPMT genotype and phenotype projects the possibility of using TPMT genotyping as a guide prior thiopurine drug administration. .
| Item Type: | Article |
|---|---|
| Journal: | Asia-Pacific Journal of Molecular Medicine |
| ID Code: | 6092 |
| Deposited By: | ms aida - |
| Deposited On: | 05 Apr 2013 11:08 |
| Last Modified: | 14 Dec 2016 06:40 |
Repository Staff Only: item control page
