Xanthones from calophyllum gracilipes and their cytotoxic activity

Nadiah Mad Nasir, and Mawardi Rahmani, and Khozirah Shaari, and Nur Kartinee Kassim, and Go, Rusea and Stanslas, Johnson and Ethel Jeyaseela Jeyaraj, (2013) Xanthones from calophyllum gracilipes and their cytotoxic activity. Sains Malaysiana, 42 (9). pp. 1261-1266. ISSN 0126-6039


Official URL: http://www.ukm.my/jsm/


Extraction and chromatographic isolation of the hexane, chloroform and methanol extracts of stem bark of Calophyllum gracilipes has led to the isolation of a new xanthone, gracixanthone (1) and the known zeyloxanthanone (2) and trapezifolixanthone (3) together with three common sterols, namely stigmasterol, friedelin and lupeol. The structures of the compounds were elucidated and established by spectroscopic analysis and compared with the spectral data from literature. The cytotoxicity of the compounds was evaluated and zeyloxanthanone (2) exhibited strong activity towards five cell lines with IC50 values ranging at 8.00-26.00 μΜ.

Item Type:Article
Keywords:Calophyllum gracilipes; gracixanthone; sterols; trapezifolixanthone; zeyloxanthanone
Journal:Sains Malaysiana
ID Code:6468
Deposited By: ms aida -
Deposited On:26 Aug 2013 01:30
Last Modified:14 Dec 2016 06:41

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