Phylogenetic analysis of respiratory syncytial virus identified at Universiti Kebangsaan Malaysia Medical Centre

Rahman, M.M. and Wong, K.K. and Isahak, I. and Rashid, Z.Z. and Alfizah, H. (2014) Phylogenetic analysis of respiratory syncytial virus identified at Universiti Kebangsaan Malaysia Medical Centre. Sains Malaysiana, 43 (5). pp. 739-744. ISSN 0126-6039

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Official URL: http://www.ukm.my/jsm/

Abstract

Human respiratory syncytial virus (RSV) is an important cause of acute respiratory tract infection in infants and young children. Phylogenetic analysis for RSV in Malaysia has not been reported before. We investigated the genetic features of RSV in respiratory specimens from March to August 2011 with molecular methods. From a total of 130 throat swab and nasopharyngeal aspirate specimens, 54 (41.5%) were positive with RSV, identified by in-house real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay. Thirty-four out of 54 (63.0%) RSV positive patients were children below two years old and two (1.4%) were adults. Phylogenetic analysis showed 39 isolates were genotype GA5, 13 genotypes GA2, one genotype GA1 and one genotype GA7. The findings indicated four genotypes of RSV circulating in the country and the predominant genotype is GA5.

Item Type:Article
Keywords:Genotype GA1, GA2, GA5 and GA7; phylogenetic analysis; respiratory syncytial virus
Journal:Sains Malaysiana
ID Code:7155
Deposited By: ms aida -
Deposited On:19 May 2014 06:18
Last Modified:14 Dec 2016 06:43

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