High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma

Mohd Rohaizad Md Roduan, and Norhafizah Mohtarrudin, and Chong, Pei Pei and Malina Osman, and Noraini Mohd Dusa, (2015) High expression of cyclooxygenase-2 in high grade human prostate adenocarcinoma. Sains Malaysiana, 44 (5). pp. 727-733. ISSN 0126-6039


Official URL: http://www.ukm.my/jsm/malay_journals/jilid44bil5_2...


Inflammation plays an important role to the process of prostate carcinogenesis by increasing the rate of cell proliferation, which contributes to an aggressive tumour phenotype. Cyclooxygenase-2 (COX-2) has been found overexpressed in various types of cancer cells including prostate. The aim of this study was to investigate the COX-2 expressions in different types of human prostate tissues. Paraffin-embedded prostate tissues from 263 samples were examined for the expression of COX-2 marker by immunohistochemistry method. COX-2 was found highly expressed in prostate adenocarcinoma (p=0.001) as compared to benign and normal tissues. The score of COX-2 expressions in most of normal prostate was weak 49 (77.8%), while only 16 (16%) of BPH showed strong expression. 56 cases (56%) prostate cancer showed strong COX-2 expression. Prostate cancer cases showed significant differences in staining patterns as tumour grade increased. In addition, COX-2 expression was significantly correlated with Gleason score in cancerous tissues. This study suggests that COX-2 overexpression is associated with prostate cancer and higher grade tumour.

Item Type:Article
Keywords:Cyclooxygenase-2 (COX-2); immunohistochemistry; inflammations; overexpression; prostate adenocarcinoma
Journal:Sains Malaysiana
ID Code:8948
Deposited By: ms aida -
Deposited On:26 Jul 2015 14:14
Last Modified:14 Dec 2016 06:48

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