Kesan in vitro rilmenidine ke atas rembesan insulin

Rosnani Hashim, and Tariq Abdul Razak, and Suhaimi Hashim, (2003) Kesan in vitro rilmenidine ke atas rembesan insulin. Jurnal Sains Kesihatan Malaysia, 1 . pp. 1-7. ISSN 1675-8161

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This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations.

Item Type:Article
Keywords:Rilmenidine; isolated pancreas; insulin secretion; peak plasma concentration
Journal:Jurnal Sains Kesihatan Malaysia
ID Code:948
Deposited By: Mr Azhari Jamaludin
Deposited On:28 Apr 2011 03:55
Last Modified:14 Dec 2016 06:28

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