Matrine enhances the inhibitory effect of 5-FU on SW480 cells in vitro and in vivo

Xu, Hui Zhang and Lei, Liang and Xiao, Yan Wang and Li, Zhang and Yan, Xin Zheng and Hong, Zhu Deng and Xin, Rong Wu (2016) Matrine enhances the inhibitory effect of 5-FU on SW480 cells in vitro and in vivo. Sains Malaysiana, 45 (1). pp. 109-113. ISSN 0126-6039


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We investigated the antitumor effects of the combination of matrine-a purified alkaloid extracted from Sophora flavescence-and 5-fluorouracil (5-FU) on SW480 cells. This combination inhibited the growth of SW480 cells in a synergistic or additive manner by disrupting their progression through the cell cycle. Exposure of SW480 cells to matrine and 5-FU was followed by an increased rate of expression for caspase-3, caspase-9 and poly-ADP ribose polymerase (PARP) and inhibited the subcutaneous transplantation of SW480 tumors into Balb/c nude mice. Histopathological analysis showed that this effect was most pronounced in the spleens of treated animals. Typical cytotoxic effects observed in 5-FU-treated mice included fibrosis and lymphopenia, whereas in mice treated with 5-FU combined with matrine, the spleen ultrastructure remained intact. These findings indicate that matrine may enhance the therapeutic effectiveness of 5-FU in SW480 tumors by enhancing apoptosis and overcome the threat to immunocompetence associated with 5-FU.

Item Type:Article
Keywords:Colorectal cancer; combination chemotherapy; cytotoxicity; Sophora flavescence; 5-fluorouracil
Journal:Sains Malaysiana
ID Code:9575
Deposited By: ms aida -
Deposited On:02 Mar 2016 07:34
Last Modified:14 Dec 2016 06:50

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