Protective effects of Citrullus vulgaris on Irradiated Lymphocyte Sub-membrane

Khairul Osman, and Norashikin Md Saad, and Ezlan Elias, and Siti Fatimah Ibrahim, and Jamaludin Mohamed, and Proom Proomwichit, (2005) Protective effects of Citrullus vulgaris on Irradiated Lymphocyte Sub-membrane. Jurnal Sains Kesihatan Malaysia, 3 (1). pp. 1-9. ISSN 1675-8161

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A study was conducted to determine the radioprotective effects of Citrullus vulgaris on the lymphocyte sub-membrane particularly the actin layer. A total of 30 adult male Sprague-Dawley rats were divided into three equal groups of positive control, negative control and treatment. The positive and negative control groups were force fed with 40 ml/kg body weight of normal saline while the treatment group received 40 g/kg body weight of fresh juice of C. vulgaris daily. After a week the positive control and treatment groups were irradiated with 90 rad gamma radiation. Viable lymphocytes were determined using propidium iodine and acridine orange stain and observed under a fluorescent microscope. The percentage of viable lymphocytes of the treatment group(71.0%; p = 0.03) was significantly higher than the positive control group. The results showed that C. vulgaris possessed radioprotective effects because the lymphocyte actin was not damaged. The radioprotection effects could be due to the presence of antioxidants in C. vulgaris.

Item Type:Article
Keywords:Radioprotection; Citrullus vulgaris; free radical; actin; lymphocytes; actin; antioxidant
Journal:Jurnal Sains Kesihatan Malaysia
ID Code:978
Deposited By: Mr Azhari Jamaludin
Deposited On:29 Apr 2011 03:34
Last Modified:14 Dec 2016 06:28

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